Chain Catalysis
- Reaction
- Affliction
- Detonation
- Area
A TierBossing · Speed farming · Mid
Overview
Overview
Two afflictions on the same target react; Volatile Mixture detonates what's left — the room turns into a string of bursts.
Good for: Late campaign, Reverberated and Echoes T1–T9: clear.
Strengths
- One of the biggest mid clears
- Area that spreads on its own
- Bosses go down well too
Weaknesses
- Fragile
- Slow flasks
- Needs the Alchemist's own Inheritance
Loadout
What the build carries
Hover or tap an icon to see what it does, in the game's own words.
- Inheritance
- CatalystWandering Alchemist
Relics8
Core
- Deep Flask
- Crown of Coal
- Thorn Censer
Recommended
- Short Focus
- Bell of Ashes
- Catalyst Vial
Optional
- Dirty Cloth
- Stone Flower
Progression
Progression trees
Explore the progression trees used in this build. Lit nodes are the ones it takes; the rest of each tree stays dimmed behind them.
Iris Fragments: 930
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Body
- Hardened Bark6/8+60% health (max +80%)
- Restoring Sap1/5+8% healing received
- Extra Flasks1/3+1 flask(s)
Power
- Sharp Gaze6/8+36% damage (max +48%)
- Steady Rhythm2/5+14% on basic attacks
Focus
- Reservoir5/5+50% maximum resource
- Serene Flow5/5110% of natural flow
- Lasting Mark4/4+48% effect duration
- Measured Haste3/4-15% cooldown (max -20%)
Fortune
- Hole in the Pocket, Reversed1/5+12% gold
- Deep Pocket3/4+3 relic slot
Constellation Point: 18
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Affliction
- Cold Blood+22% Affliction Damage · +16% Affliction Duration
- Dirty Hand+1 Stacks
- +7% Affliction Damage ×3 · +8% Affliction Duration ×2 · +6% Affliction Chance · +6% Affliction Rate
Area
- Wide Wave+22% Size · +12% Damage with Area
- +8% Damage with Area · +8% Size
RELIC SLOTS: +1
In practice
How to play
Open with Unstable Dose.
Keep fire and poison on the same targets.
Against packs, chain bursts.
Against bosses, stack and detonate.
Careful: detonating early wastes marks.
To keep
The build card
The whole build in one image: ratings, loadout, trees and how to play.
Open the cardMeasured on Sep 28, 2026 · game v1.0.1 · test bench v8
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